| Tissue Specificity | Abundantly expressed in brain, heart and testis. Also detected in kidney and pancreatic islets. |
| Post Translational Modifications | Citrullinated by PADI4. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation. On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth. |
| Protein Name | Ras-Related Protein Rab-11b |
| Database Links | Reactome: R-MMU-8854214Reactome: -MMU-8873719 |
| Cellular Localisation | Recycling Endosome MembraneLipid-AnchorCytoplasmic SideCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembranePhagosome MembraneColocalizes With Rab11afip1 On Punctate Vesicles |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-11b antibodyAnti-Rab11b antibody |
Information sourced from Uniprot.org
