| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PTPN4 (1-240) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PTPN4 |
| Gene ID: |
5775 |
| Uniprot ID: |
PTN4_HUMAN |
| Immunogen Region: |
1-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PTPN4 (NP_002821.1). |
| Immunogen Sequence: |
MTSRFRLPAGRTYNVRASEL ARDRQHTEVVCNILLLDNTV QAFKVNKHDQGQVLLDVVFK HLDLTEQDYFGLQLADDSTD NPRWLDPNKPIRKQLKRGSP YSLNFRVKFFVSDPNKLQEE YTRYQYFLQIKQDILTGRLP CPSNTAALLASFAVQSELGD YDQSENLSGYLSDYSFIPNQ PQDFEKEIAKLHQQHIGLSP AEAEFNYLNTARTLELYGVE FHYARDQSNNEIMIGVMSG |
| Post Translational Modifications | Highly phosphorylated on serine and threonine residues but not on tyrosines. Cleaved and activated by calpain I/CAPN1. |
| Function | Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis. Regulates neuronal cell homeostasis by protecting neurons against apoptosis. Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction. Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway. May act at junctions between the membrane and the cytoskeleton. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 4Protein-Tyrosine Phosphatase Meg1MegPtpase-Meg1 |
| Database Links | Reactome: R-HSA-166016Reactome: R-HSA-9008059Reactome: R-HSA-9022699 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 4 antibodyAnti-Protein-Tyrosine Phosphatase Meg1 antibodyAnti-Meg antibodyAnti-Ptpase-Meg1 antibodyAnti-PTPN4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
