Anti-PTPN4 antibody (1-240) (STJ26538)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PTPN4 (1-240) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PTPN4 |
| Gene ID | 5775 |
| Uniprot ID | PTN4_HUMAN |
| Immunogen Region | 1-240 |
| Immunogen Sequence | MTSRFRLPAGRTYNVRASEL ARDRQHTEVVCNILLLDNTV QAFKVNKHDQGQVLLDVVFK HLDLTEQDYFGLQLADDSTD NPRWLDPNKPIRKQLKRGSP YSLNFRVKFFVSDPNKLQEE YTRYQYFLQIKQDILTGRLP CPSNTAALLASFAVQSELGD YDQSENLSGYLSDYSFIPNQ PQDFEKEIAKLHQQHIGLSP AEAEFNYLNTARTLELYGVE FHYARDQSNNEIMIGVMSG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PTPN4 (NP_002821.1). |
Additional Info
| Post Translational Modifications | Highly phosphorylated on serine and threonine residues but not on tyrosines. Cleaved and activated by calpain I/CAPN1. |
| Function | Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis. Regulates neuronal cell homeostasis by protecting neurons against apoptosis. Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction. Also dephosphorylates the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway. May act at junctions between the membrane and the cytoskeleton. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 4Protein-Tyrosine Phosphatase Meg1MegPtpase-Meg1 |
| Database Links | Reactome: R-HSA-166016Reactome: R-HSA-9008059Reactome: R-HSA-9022699 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 4 antibodyAnti-Protein-Tyrosine Phosphatase Meg1 antibodyAnti-Meg antibodyAnti-Ptpase-Meg1 antibodyAnti-PTPN4 antibody |
Information sourced from Uniprot.org