![Anti-PTGES3 antibody (1-100) [S9MR] (STJ11102289)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/91206/362298/STJ11102289_1__99250.1713127316.jpg?c=1 "Anti-PTGES3 antibody (1-100) [S9MR] (STJ11102289)")
![Anti-PTGES3 antibody (1-100) [S9MR] (STJ11102289)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/91206/362298/STJ11102289_1__99250.1713127316.jpg?c=1 "Anti-PTGES3 antibody (1-100) [S9MR] (STJ11102289)")
| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S9MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTGES3 |
| Gene ID: | 10728 |
| Uniprot ID: | TEBP_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human P23/PTGES3 (NP_006592.3). |
| Immunogen Sequence: | MQPASAKWYDRRDYVFIEFC VEDSKDVNVNFEKSKLTFSC LGGSDNFKHLNEIDLFHCID PNDSKHKRTDRSILCCLRKG ESGQSWPRLTKERAKLNWLS |
| Post Translational Modifications | Proteolytically cleaved by caspase-7 (CASP7) in response to apoptosis, leading to its inactivation. |
| Function | Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. |
| Protein Name | Prostaglandin E Synthase 3Cytosolic Prostaglandin E2 SynthaseCpgesHsp90 Co-ChaperoneProgesterone Receptor Complex P23Telomerase-Binding Protein P23 |
| Database Links | Reactome: R-HSA-2162123Reactome: R-HSA-3371497Reactome: R-HSA-3371511Reactome: R-HSA-3371568Reactome: R-HSA-8937144Reactome: R-HSA-8939211Reactome: R-HSA-9018519Reactome: R-HSA-9679191 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Prostaglandin E Synthase 3 antibodyAnti-Cytosolic Prostaglandin E2 Synthase antibodyAnti-Cpges antibodyAnti-Hsp90 Co-Chaperone antibodyAnti-Progesterone Receptor Complex P23 antibodyAnti-Telomerase-Binding Protein P23 antibodyAnti-PTGES3 antibodyAnti-P23 antibodyAnti-TEBP antibody |
Information sourced from Uniprot.org
![Immunoprecipitation analysis of 300 Mu g extracts from 293T cells using 3 Mu g [KO Validated] ATG5 Rabbit monoclonal antibody (STJ11101759). Western blot was performed from the immunoprecipitate using [KO Validated] ATG5 Rabbit monoclonal antibody (STJ11101759) at a dilution of 1:1000.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/90674/360687/STJ11101759_1__34437.1713125386.jpg?c=1 "Immunoprecipitation analysis of 300 Mu g extracts from 293T cells using 3 Mu g [KO Validated] ATG5 Rabbit monoclonal antibody (STJ11101759). Western blot was performed from the immunoprecipitate using [KO Validated] ATG5 Rabbit monoclonal antibody (STJ11101759) at a dilution of 1:1000.")
