Anti-PTGES antibody (42-59 aa) [R03-8E7] (STJA0011835)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human Prostaglandin E Synthase
General Information
| Short Description | Rabbit monoclonal anti-Prostaglandin E Synthase (42-59 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-8E7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PTGES |
| Gene ID | 9536 |
| Uniprot ID | PTGES_HUMAN |
| Immunogen | A synthetic peptide of human Prostaglandin E Synthase |
| Immunogen Region | 42-59 aa |
Additional Info
| Function | Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli. Plays a key role in inflammation response, fever and pain. Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively. |
| Protein Name | Prostaglandin E SynthaseGlutathione Peroxidase PtgesGlutathione Transferase PtgesMicrosomal Glutathione S-Transferase 1-Like 1Mgst1-L1Microsomal Prostaglandin E Synthase 1Mpges-1P53-Induced Gene 12 Protein |
| Database Links | Reactome: R-HSA-2162123 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCytoplasmPerinuclear RegionColocalizes With Ptgs1/Cox-1 And Ptgs2/Cox-2 In The Perinuclear Compartment |
| Alternative Antibody Names | Anti-Prostaglandin E Synthase antibodyAnti-Glutathione Peroxidase Ptges antibodyAnti-Glutathione Transferase Ptges antibodyAnti-Microsomal Glutathione S-Transferase 1-Like 1 antibodyAnti-Mgst1-L1 antibodyAnti-Microsomal Prostaglandin E Synthase 1 antibodyAnti-Mpges-1 antibodyAnti-P53-Induced Gene 12 Protein antibodyAnti-PTGES antibodyAnti-MGST1L1 antibodyAnti-MPGES1 antibodyAnti-PGES antibodyAnti-PIG12 antibody |
Information sourced from Uniprot.org