![Anti-PTCH1 nanobody [SAA1343] (STJN000266)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200879/413061/STJN000266-SDS-PAGE-1__42667.1749232570.jpg?c=1 "Anti-PTCH1 nanobody [SAA1343] (STJN000266)")
![Anti-PTCH1 nanobody [SAA1343] (STJN000266)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200879/413061/STJN000266-SDS-PAGE-1__42667.1749232570.jpg?c=1 "Anti-PTCH1 nanobody [SAA1343] (STJN000266)")
Anti-PTCH1 nanobody [SAA1343] (STJN000266)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Protein Patched Homolog 1 is suitable for use in BImmunofluorescence and ELISA research applications. |
| Applications | BIF/ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1343 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | PTCH1 |
| Gene ID | 5727 |
| Uniprot ID | PTC1_HUMAN |
Additional Info
| Post Translational Modifications | Glycosylation is necessary for SHH binding. In the absence of Hh ligands, ubiquitination by ITCH at Lys-1426 promotes endocytosis and both proteasomal and lysosomal degradation. |
| Function | Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. |
| Protein Name | Protein Patched Homolog 1PtcPtc1 |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-5610787Reactome: R-HSA-5632681Reactome: R-HSA-5632684Reactome: R-HSA-5635838 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Nanobody Names | Anti-Protein Patched Homolog 1 nanobodyAnti-Ptc nanobodyAnti-Ptc1 nanobodyAnti-PTCH1 nanobodyAnti-PTCH nanobody |
Information sourced from Uniprot.org