| Host: |
Alpaca |
| Applications: |
BIF/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : |
Alpaca monoclonal nanobody anti-Protein Patched Homolog 1 is suitable for use in BImmunofluorescence and ELISA research applications. |
| Clonality : |
Monoclonal |
| Clone ID : |
SAA1343 |
| Conjugation: |
Unconjugated |
| Isotype: |
VHH-8His-Cys-tag |
| Formulation: |
0.01M PBS, pH 7.4. |
| Purification: |
Purified by Nickel column. |
| Concentration: |
1 mg/mL |
| Storage Instruction: |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
| Post Translational Modifications | Glycosylation is necessary for SHH binding. In the absence of Hh ligands, ubiquitination by ITCH at Lys-1426 promotes endocytosis and both proteasomal and lysosomal degradation. |
| Function | Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. |
| Protein Name | Protein Patched Homolog 1PtcPtc1 |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-5610787Reactome: R-HSA-5632681Reactome: R-HSA-5632684Reactome: R-HSA-5635838 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Nanobody Names | Anti-Protein Patched Homolog 1 nanobodyAnti-Ptc nanobodyAnti-Ptc1 nanobodyAnti-PTCH1 nanobodyAnti-PTCH nanobody |
Information sourced from Uniprot.org
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