| Short Description : | Rabbit polyclonal PSMG1 (1-288) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:200-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PSMG1 |
| Gene ID: | 8624 |
| Uniprot ID: | PSMG1_HUMAN |
| Immunogen Region: | 1-288 |
| Immunogen Sequence: | MAATFFGEVVKAPCRAGTED EEEEEEGRRETPEDREVRLQ LARKREVRLLRRQTKTSLEV SLLEKYPCSKFIIAIGNNAV AFLSSFVMNSGVWEEVGCAK LWNEWCRTTDTTHLSSTEAF CVFYHLKSNPSVFLCQCSCY VAEDQQYQWLEKVFGSCPRK NMQITILTCRHVTDYKTSES TGSLPSPFLRALKTQNFKDS ACCPLLEQPNIVHDLPAAVL SYCQVWKIPAILYLCYTDV |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-288 of human PSMG1 (NP_003711.1). |
| Tissue Specificity | In the adult, detected in brain, colon, leukocytes, breast and testis. Widely expressed in the fetus. Also expressed in a variety of proliferating cell lines. |
| Post Translational Modifications | Degraded by the proteasome upon completion of 20S proteasome maturation. |
| Function | Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. |
| Protein Name | Proteasome Assembly Chaperone 1Pac-1Chromosome 21 Leucine-Rich ProteinC21-LrpDown Syndrome Critical Region Protein 2Proteasome Chaperone Homolog 1Pba1 |
| Database Links | Reactome: R-HSA-9907900 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Proteasome Assembly Chaperone 1 antibodyAnti-Pac-1 antibodyAnti-Chromosome 21 Leucine-Rich Protein antibodyAnti-C21-Lrp antibodyAnti-Down Syndrome Critical Region Protein 2 antibodyAnti-Proteasome Chaperone Homolog 1 antibodyAnti-Pba1 antibodyAnti-PSMG1 antibodyAnti-C21LRP antibodyAnti-DSCR2 antibodyAnti-PAC1 antibody |
Information sourced from Uniprot.org
