| Short Description : | Rabbit polyclonal PSMD4 (1-377) antibody for use in WB, IF, ICC, IP and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/IP/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PSMD4 |
| Gene ID: | 5710 |
| Uniprot ID: | PSMD4_HUMAN |
| Immunogen Region: | 1-377 |
| Immunogen Sequence: | MVLESTMVCVDNSEYMRNGD FLPTRLQAQQDAVNIVCHSK TRSNPENNVGLITLANDCEV LTTLTPDTGRILSKLHTVQP KGKITFCTGIRVAHLALKHR QGKNHKMRIIAFVGSPVEDN EKDLVKLAKRLKKEKVNVDI INFGEEEVNTEKLTAFVNTL NGKDGTGSHLVTVPPGPSLA DALISSPILAGEGGAMLGLG ASDFEFGVDPSADPELALAL RVSMEEQRQRQEEEARRAA |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-377 of human PSMD4 (NP_002801.1). |
| Function | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. |
| Protein Name | 26s Proteasome Non-Atpase Regulatory Subunit 426s Proteasome Regulatory Subunit Rpn1026s Proteasome Regulatory Subunit S5aAntisecretory Factor 1AfAsfMultiubiquitin Chain-Binding Protein |
| Database Links | Reactome: R-HSA-9907900 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-26s Proteasome Non-Atpase Regulatory Subunit 4 antibodyAnti-26s Proteasome Regulatory Subunit Rpn10 antibodyAnti-26s Proteasome Regulatory Subunit S5a antibodyAnti-Antisecretory Factor 1 antibodyAnti-Af antibodyAnti-Asf antibodyAnti-Multiubiquitin Chain-Binding Protein antibodyAnti-PSMD4 antibodyAnti-MCB1 antibody |
Information sourced from Uniprot.org
