![Anti-Progesterone antibody [EBS-O-048] (STJ16100991)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149707/302447/STJ16100991_1__00517.1646940638.jpg?c=1 "Anti-Progesterone antibody [EBS-O-048] (STJ16100991)")
![Anti-Progesterone antibody [EBS-O-048] (STJ16100991)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149707/302447/STJ16100991_1__00517.1646940638.jpg?c=1 "Anti-Progesterone antibody [EBS-O-048] (STJ16100991)")
Anti-Progesterone antibody [EBS-O-048] (STJ16100991)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenA BALB/c mouse was immunized with Progesterone-11a-hemisuccinate conjugated to BSA (Progesterone-11a-HMS-BSA). Fusion partner: X63-Ag8-653.
General Information
| Short Description | Mouse monoclonal anti-Progesterone for use in ELISA in All Species samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | All Species |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | EBS-O-048 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL. |
| Purification | Affinity purified from tissue culture. |
| Dilution Range | ELISA (solid phase: 0, 1-100 µg/ml; tracer: 0, 001-100 µg/ml for 30 min at RT). |
| Formulation | PBS with 0.02% Sodium Azide. |
| Storage Instruction | Store for up to 1 year at 2-8°C upon receipt. |
Target Information
| Gene Symbol | PGRMC2 |
| Gene ID | 10424 |
| Uniprot ID | PGRC2_HUMAN |
| Immunogen | A BALB/c mouse was immunized with Progesterone-11a-hemisuccinate conjugated to BSA (Progesterone-11a-HMS-BSA). Fusion partner: X63-Ag8-653. |
Additional Info
| Tissue Specificity | Expressed by endometrial glands and stroma (at protein level). Detected in urine (at protein level). |
| Function | Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1. |
| Protein Name | Membrane-Associated Progesterone Receptor Component 2Progesterone Membrane-Binding ProteinSteroid Receptor Protein Dg6 |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013408Reactome: R-HSA-9013423Reactome: R-HSA-9707616 |
| Cellular Localisation | MembraneSingle-Pass Membrane ProteinNucleus EnvelopeEndoplasmic ReticulumSecreted |
| Alternative Antibody Names | Anti-Membrane-Associated Progesterone Receptor Component 2 antibodyAnti-Progesterone Membrane-Binding Protein antibodyAnti-Steroid Receptor Protein Dg6 antibodyAnti-PGRMC2 antibodyAnti-DG6 antibodyAnti-PMBP antibody |
Information sourced from Uniprot.org