| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PRMT6 (1-375) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PRMT6 |
| Gene ID: |
55170 |
| Uniprot ID: |
ANM6_HUMAN |
| Immunogen Region: |
1-375 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-375 of human PRMT6 (NP_060607.2). |
| Immunogen Sequence: |
MSQPKKRKLESGGGGEGGEG TEEEDGAEREAALERPRRTK RERDQLYYECYSDVSVHEEM IADRVRTDAYRLGILRNWAA LRGKTVLDVGAGTGILSIFC AQAGARRVYAVEASAIWQQA REVVRFNGLEDRVHVLPGPV ETVELPEQVDAIVSEWMGYG LLHESMLSSVLHARTKWLKE GGLLLPASAELFIAPISDQM LEWRLGFWSQVKQHYGVDMS CLEGFATRCLMGHSEIVVQ |
| Tissue Specificity | Highly expressed in kidney and testis. |
| Post Translational Modifications | Automethylation enhances its stability and antiretroviral activity. |
| Function | Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence. Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC). Methylates GPS2, protecting GPS2 from ubiquitination and degradation. Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis. |
| Protein Name | Protein Arginine N-Methyltransferase 6Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 6Histone-Arginine N-Methyltransferase Prmt6 |
| Database Links | Reactome: R-HSA-3214858Reactome: R-HSA-8936459 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Protein Arginine N-Methyltransferase 6 antibodyAnti-Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 6 antibodyAnti-Histone-Arginine N-Methyltransferase Prmt6 antibodyAnti-PRMT6 antibodyAnti-HRMT1L6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
