Anti-PRMT2 antibody (Internal) (STJ72813)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-PRMT2 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 37kDa band observed in lysates of cell line HeLa and in rodent Brain lysates (calculated MW of 37.2kDa according to NP_001229793.1). Approx 35kDa band observed in Pig Brain lysa |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PRMT2 |
| Gene ID | 3275 |
| Uniprot ID | ANM2_HUMAN |
| Accession Number | NP_001526.2; NP_001229793.1; NP_001229794.1; NP_001229795.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | DQPRTTKYHSVILQ |
| Specificity | This antibody is expected to recognize all reported isoforms (NP_001526.2; NP_001229793.1; NP_001229794.1; NP_001229795.1). Reported variants represent identical protein: NP_001526.2, NP_996845.1 |
Additional Info
| Function | Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation. |
| Protein Name | Protein Arginine N-Methyltransferase 2Histone-Arginine N-Methyltransferase Prmt2 |
| Cellular Localisation | Isoform 1: CytoplasmNucleusTranslocates From The Cytoplasm To The NucleusAfter Hormone ExposureExcluded From NucleolusIsoform Prmt2alpha: NucleusIsoform Prmt2beta: CytoplasmNucleolusIsoform Prmt2gamma: NucleusIsoform Prmt2l2: CytoplasmPredominantly Cytoplasmic |
| Alternative Antibody Names | Anti-Protein Arginine N-Methyltransferase 2 antibodyAnti-Histone-Arginine N-Methyltransferase Prmt2 antibodyAnti-PRMT2 antibodyAnti-HMT1 antibodyAnti-HRMT1L1 antibody |
Information sourced from Uniprot.org