| Short Description : | Goat polyclonal antibody anti-PRMT2 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications: | Pep-ELISA/WB |
| Host: | Goat |
| Reactivity: | Human/Mouse/Rat/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.5 mg/mL |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 37kDa band observed in lysates of cell line HeLa and in rodent Brain lysates (calculated MW of 37.2kDa according to NP_001229793.1). Approx 35kDa band observed in Pig Brain lysa |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | PRMT2 |
| Gene ID: | 3275 |
| Uniprot ID: | ANM2_HUMAN |
| Accession Number: | NP_001526.2; NP_001229793.1; NP_001229794.1; NP_001229795.1 |
| Immunogen Region: | Internal |
| Immunogen Sequence: | DQPRTTKYHSVILQ |
| Specificity: | This antibody is expected to recognize all reported isoforms (NP_001526.2; NP_001229793.1; NP_001229794.1; NP_001229795.1). Reported variants represent identical protein: NP_001526.2, NP_996845.1 |
| Function | Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation. |
| Protein Name | Protein Arginine N-Methyltransferase 2Histone-Arginine N-Methyltransferase Prmt2 |
| Cellular Localisation | Isoform 1: CytoplasmNucleusTranslocates From The Cytoplasm To The NucleusAfter Hormone ExposureExcluded From NucleolusIsoform Prmt2alpha: NucleusIsoform Prmt2beta: CytoplasmNucleolusIsoform Prmt2gamma: NucleusIsoform Prmt2l2: CytoplasmPredominantly Cytoplasmic |
| Alternative Antibody Names | Anti-Protein Arginine N-Methyltransferase 2 antibodyAnti-Histone-Arginine N-Methyltransferase Prmt2 antibodyAnti-PRMT2 antibodyAnti-HMT1 antibodyAnti-HRMT1L1 antibody |
Information sourced from Uniprot.org
![Immunofluorescence analysis of HeLa cells using [KO Validated] PRMT2 Rabbit polyclonal antibody (STJ28398). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/101688/389745/STJ28398_1__85710.1713159476.jpg?c=1 "Immunofluorescence analysis of HeLa cells using [KO Validated] PRMT2 Rabbit polyclonal antibody (STJ28398). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution.")
