| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PRMT2 (1-300) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PRMT2 |
| Gene ID: |
3275 |
| Uniprot ID: |
ANM2_HUMAN |
| Immunogen Region: |
1-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PRMT2 (NP_996845.1). |
| Immunogen Sequence: |
MATSGDCPRSESQGEEPAEC SEAGLLQEGVQPEEFVAIAD YAATDETQLSFLRGEKILIL RQTTADWWWGERAGCCGYIP ANHVGKHVDEYDPEDTWQDE EYFGSYGTLKLHLEMLADQP RTTKYHSVILQNKESLTDKV ILDVGCGTGIISLFCAHYAR PRAVYAVEASEMAQHTGQLV LQNGFADIITVYQQKVEDVV LPEKVDVLVSEWMGTCLLFE FMIESILYARDAWLKEDGV |
| Tissue Specificity | Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord. |
| Function | Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation. |
| Protein Name | Protein Arginine N-Methyltransferase 2Histone-Arginine N-Methyltransferase Prmt2 |
| Cellular Localisation | Isoform 1: CytoplasmNucleusTranslocates From The Cytoplasm To The NucleusAfter Hormone ExposureExcluded From NucleolusIsoform Prmt2alpha: NucleusIsoform Prmt2beta: CytoplasmNucleolusIsoform Prmt2gamma: NucleusIsoform Prmt2l2: CytoplasmPredominantly Cytoplasmic |
| Alternative Antibody Names | Anti-Protein Arginine N-Methyltransferase 2 antibodyAnti-Histone-Arginine N-Methyltransferase Prmt2 antibodyAnti-PRMT2 antibodyAnti-HMT1 antibodyAnti-HRMT1L1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and BUB1 knockout (KO) HeLa cells, using [KO Validated] BUB1 Rabbit polyclonal antibody (STJ11100026) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89098/357557/STJ11100026_1__69013.1713121681.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and BUB1 knockout (KO) HeLa cells, using [KO Validated] BUB1 Rabbit polyclonal antibody (STJ11100026) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.")
