Anti-PRKAR1A antibody (1-250) (STJ25122)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PRKAR1A (1-250) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRKAR1A |
| Gene ID | 5573 |
| Uniprot ID | KAP0_HUMAN |
| Immunogen Region | 1-250 |
| Immunogen Sequence | MESGSTAASEEARSLRECEL YVQKHNIQALLKDSIVQLCT ARPERPMAFLREYFERLEKE EAKQIQNLQKAGTRTDSRED EISPPPPNPVVKGRRRRGAI SAEVYTEEDAASYVRKVIPK DYKTMAALAKAIEKNVLFSH LDDNERSDIFDAMFSVSFIA GETVIQQGDEGDNFYVIDQG ETDVYVNNEWATSVGEGGSF GELALIYGTPRAATVKAKTN VKLWGIDRDSYRRILMGST |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human PRKAR1A (NP_002725.1). |
Additional Info
| Tissue Specificity | Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. |
| Post Translational Modifications | The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity. |
| Function | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. |
| Protein Name | Camp-Dependent Protein Kinase Type I-Alpha Regulatory SubunitTissue-Specific Extinguisher 1Tse1 |
| Database Links | Reactome: R-HSA-163615Reactome: R-HSA-164378Reactome: R-HSA-180024Reactome: R-HSA-381676Reactome: R-HSA-432040Reactome: R-HSA-442720Reactome: R-HSA-5610787Reactome: R-HSA-9634597Reactome: R-HSA-9660821Reactome: R-HSA-9664323Reactome: R-HSA-9700645Reactome: R-HSA-9725370Reactome: R-HSA-983231Reactome: R-HSA-9856530 |
| Cellular Localisation | Cell Membrane |
| Alternative Antibody Names | Anti-Camp-Dependent Protein Kinase Type I-Alpha Regulatory Subunit antibodyAnti-Tissue-Specific Extinguisher 1 antibodyAnti-Tse1 antibodyAnti-PRKAR1A antibodyAnti-PKR1 antibodyAnti-PRKAR1 antibodyAnti-TSE1 antibody |
Information sourced from Uniprot.org