| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRKAR1A |
| Gene ID: | 5573 |
| Uniprot ID: | KAP0_HUMAN |
| Immunogen Region: | 1-250 |
| Immunogen Sequence: | MESGSTAASEEARSLRECEL YVQKHNIQALLKDSIVQLCT ARPERPMAFLREYFERLEKE EAKQIQNLQKAGTRTDSRED EISPPPPNPVVKGRRRRGAI SAEVYTEEDAASYVRKVIPK DYKTMAALAKAIEKNVLFSH LDDNERSDIFDAMFSVSFIA GETVIQQGDEGDNFYVIDQG ETDVYVNNEWATSVGEGGSF GELALIYGTPRAATVKAKTN VKLWGIDRDSYRRILMGST |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human PRKAR1A (NP_002725.1). |
| Tissue Specificity | Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. |
| Post Translational Modifications | The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity. |
| Function | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. |
| Protein Name | Camp-Dependent Protein Kinase Type I-Alpha Regulatory SubunitTissue-Specific Extinguisher 1Tse1 |
| Database Links | Reactome: R-HSA-163615Reactome: R-HSA-164378Reactome: R-HSA-180024Reactome: R-HSA-381676Reactome: R-HSA-432040Reactome: R-HSA-442720Reactome: R-HSA-5610787Reactome: R-HSA-9634597Reactome: R-HSA-9660821Reactome: R-HSA-9664323Reactome: R-HSA-9700645Reactome: R-HSA-9725370Reactome: R-HSA-983231Reactome: R-HSA-9856530 |
| Cellular Localisation | Cell Membrane |
| Alternative Antibody Names | Anti-Camp-Dependent Protein Kinase Type I-Alpha Regulatory Subunit antibodyAnti-Tissue-Specific Extinguisher 1 antibodyAnti-Tse1 antibodyAnti-PRKAR1A antibodyAnti-PKR1 antibodyAnti-PRKAR1 antibodyAnti-TSE1 antibody |
Information sourced from Uniprot.org
