Anti-Pre-pro-AVP antibody (STJA0005237)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide corresponding to key amino acid residues surrounding the cleavage sites for the human vasopressin precursor peptide, conjugated to keyhole limpet hemocyanin (KLH).
General Information
| Short Description | Rabbit polyclonal anti-Pre-pro-Vasopressin for use in WB, IHC and ICC in Human, Mouse, Rat and Non-Human Primates samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/ICC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat/Non-Human Primates |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Antigen Affinity Purified from Pooled Serum |
| Dilution Range | WB 1:1000IHC 1:1000ICC 1:1000 |
| Formulation | 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AVP |
| Gene ID | 551 |
| Uniprot ID | NEU2_HUMAN |
| Immunogen | Synthetic peptide corresponding to key amino acid residues surrounding the cleavage sites for the human vasopressin precursor peptide, conjugated to keyhole limpet hemocyanin (KLH). |
| Specificity | Specific for locally produced levels of the ~ 20 kDa uncleaved pre-pro-vasopressin protein. Immunolabeling of the uncleaved pre-pro-vasopressin protein band is completely blocked by preadsorption of the antibody with the peptide used as antigen. |
Additional Info
| Function | Neurophysin 2: Specifically binds vasopressin. Arg-vasopressin: Has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2). |
| Protein Name | Vasopressin-Neurophysin 2-CopeptinAvp-Npii Cleaved Into - Arg-VasopressinArginine-Vasopressin - Neurophysin 2Neurophysin-Ii - Copeptin |
| Database Links | Reactome: R-HSA-1368108Reactome: R-HSA-388479Reactome: R-HSA-416476Reactome: R-HSA-418555Reactome: R-HSA-432040Reactome: R-HSA-5619099Reactome: R-HSA-879518Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-9036092 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Vasopressin-Neurophysin 2-Copeptin antibodyAnti-Avp-Npii Cleaved Into - Arg-Vasopressin antibodyAnti-Arginine-Vasopressin - Neurophysin 2 antibodyAnti-Neurophysin-Ii - Copeptin antibodyAnti-AVP antibodyAnti-ARVP antibodyAnti-VP antibody |
Information sourced from Uniprot.org