Anti-PPP6C antibody [R47-9A-4] (STJA0035559)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human PPP6C
General Information
| Short Description | Rabbit monoclonal anti-PPP6C for use in WB, ICC, IF and FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF/FC |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R47-9A-4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200FC 1:50 |
| Formulation | Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PPP6C |
| Gene ID | 5537 |
| Uniprot ID | PPP6_HUMAN |
| Immunogen | A synthesized peptide derived from human PPP6C |
Additional Info
| Tissue Specificity | Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen. |
| Function | Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Also participates in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation. Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1. CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it. |
| Protein Name | Serine/Threonine-Protein Phosphatase 6 Catalytic SubunitPp6c Cleaved Into - Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit - N-Terminally Processed |
| Database Links | Reactome: R-HSA-171319Reactome: R-HSA-204005 |
| Cellular Localisation | MitochondrionCytoplasm |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit antibodyAnti-Pp6c Cleaved Into - Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit - N-Terminally Processed antibodyAnti-PPP6C antibodyAnti-PPP6 antibody |
Information sourced from Uniprot.org