Anti-PPP4R1 antibody (324-647) (STJ110659)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PPP4R1 (324-647) antibody for use in WB, IP and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PPP4R1 |
| Gene ID | 9989 |
| Uniprot ID | PP4R1_HUMAN |
| Immunogen Region | 324-647 |
| Immunogen Sequence | NPSSSGQYFKEESKSSEEMS VENKNRTRDQEAPEDVQVRP EDTPSDLSVSNSSVILENTM EDHAAEASGKPLGEISVPLD SSLLCTLSSESHQEAASNEN DKKPGNYKSMLRPEVGTTSQ DSALLDQELYNSFHFWRTPL PEIDLDIELEQNSGGKPSPE GPEEESEGPVPSSPNITMAT RKELEEMIENLEPHIDDPDV KAQVEVLSAALRASSLDAHE ETISIEKRSDLQDELDINE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 324-647 of human PPP4R1 (NP_001035847.1). |
Additional Info
| Tissue Specificity | Widely expressed with high expression in cultured mesangial cells. Isoform 1 and isoform 2 are expressed in renal tissues. |
| Function | Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Plays a role in the inhibition of TNF-induced NF-kappa-B activation by regulating the dephosphorylation of TRAF2. (Microbial infection) Participates in merkel polyomavirus-mediated inhibition of NF-kappa-B by bridging viral small tumor antigen with NEMO. |
| Protein Name | Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 1 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 1 antibodyAnti-PPP4R1 antibodyAnti-MEG1 antibodyAnti-PP4R1 antibody |
Information sourced from Uniprot.org