• Immunofluorescence analysis of U2OS cells using PPP2R4 antibody (STJ25089). Blue: DAPI for nuclear staining.
  • Immunohistochemistry of paraffin-embedded human esophageal cancer using PPP2R4 Antibody (STJ25089) at dilution of 1:200 (40x lens).
  • Immunohistochemistry of paraffin-embedded mouse kidney using PPP2R4 Antibody (STJ25089) at dilution of 1:200 (40x lens).
  • Immunohistochemistry of paraffin-embedded rat brain using PPP2R4 Antibody (STJ25089) at dilution of 1:200 (40x lens).

Anti-PPP2R4 antibody (STJ25089)

SKU:
STJ25089

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Host: Rabbit
Applications: IHC, IF
Reactivity: Human, Mouse
Short Description: Rabbit polyclonal anti-PPP2R4 antibody is suitable for use in Immunohistochemistry and Immunofluorescence.
Note: FOR RESEARCH USE ONLY (RUO).
Clonality: Polyclonal
Conjugation: Unconjugated
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification: Affinity purification
Storage Instruction: Store at-20°C. Avoid freeze/thaw cycles.
Isotype: IgG
Dilution Range: IHC: 1:50-1:200
IF: 1:50-1:200
Uniprot ID: PTPA_HUMAN
Gene ID: 5524
Gene Symbol: PTPA
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human PPP2R4 (NP_821067.1).
Tissue Specificity Widely expressed.
Function PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis.the function appears to be independent from PP2A.
Protein Name Serine/Threonine-Protein Phosphatase 2a Activator
Pp2a - Subunit B' - Pr53 Isoform
Phosphotyrosyl Phosphatase Activator
Ptpa
Serine/Threonine-Protein Phosphatase 2a Regulatory Subunit 4
Serine/Threonine-Protein Phosphatase 2a Regulatory Subunit B'
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Serine/Threonine-Protein Phosphatase 2a Activator antibody
Anti-Pp2a - Subunit B' - Pr53 Isoform antibody
Anti-Phosphotyrosyl Phosphatase Activator antibody
Anti-Ptpa antibody
Anti-Serine/Threonine-Protein Phosphatase 2a Regulatory Subunit 4 antibody
Anti-Serine/Threonine-Protein Phosphatase 2a Regulatory Subunit B' antibody
Anti-PTPA antibody
Anti-PPP2R4 antibody

Information sourced from Uniprot.org

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