||Rabbit polyclonal anti-PPP2R4 antibody is suitable for use in Immunohistochemistry and Immunofluorescence.
||FOR RESEARCH USE ONLY (RUO).
||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
||Store at-20°C. Avoid freeze/thaw cycles.
||IHC: 1:50-1:200IF: 1:50-1:200
||Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human PPP2R4 (NP_821067.1).
| Tissue Specificity || Widely expressed. |
| Function || PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis.the function appears to be independent from PP2A. |
| Protein Name || Serine/Threonine-Protein Phosphatase 2a ActivatorPp2a - Subunit B' - Pr53 IsoformPhosphotyrosyl Phosphatase ActivatorPtpaSerine/Threonine-Protein Phosphatase 2a Regulatory Subunit 4Serine/Threonine-Protein Phosphatase 2a Regulatory Subunit B' |
| Cellular Localisation || CytoplasmNucleus |
| Alternative Antibody Names || Anti-Serine/Threonine-Protein Phosphatase 2a Activator antibodyAnti-Pp2a - Subunit B' - Pr53 Isoform antibodyAnti-Phosphotyrosyl Phosphatase Activator antibodyAnti-Ptpa antibodyAnti-Serine/Threonine-Protein Phosphatase 2a Regulatory Subunit 4 antibodyAnti-Serine/Threonine-Protein Phosphatase 2a Regulatory Subunit B' antibodyAnti-PTPA antibodyAnti-PPP2R4 antibody |
Information sourced from Uniprot.org
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