Anti-PPP2R4 antibody (1-323) (STJ25089)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PPP2R4 (1-323) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:6000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PTPA |
| Gene ID | 5524 |
| Uniprot ID | PTPA_HUMAN |
| Immunogen Region | 1-323 |
| Immunogen Sequence | MAEGERQPPPDSSEEAPPAT QNFIIPKKEIHTVPDMGKWK RSQAYADYIGFILTLNEGVK GKKLTFEYRVSEAIEKLVAL LNTLDRWIDETPPVDQPSRF GNKAYRTWYAKLDEEAENLV ATVVPTHLAAAVPEVAVYLK ESVGNSTRIDYGTGHEAAFA AFLCCLCKIGVLRVDDQIAI VFKVFNRYLEVMRKLQKTYR MEPAGSQGVWGLDDFQFLPF IWGSSQLIDHPYLEPRHFV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human Ser/thr-PP2A activator (PTPA) (NP_821067.1). |
Additional Info
| Tissue Specificity | Widely expressed. |
| Function | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A). Modulates PP2A activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis.the function appears to be independent from PP2A. |
| Protein Name | Serine/Threonine-Protein Phosphatase 2a ActivatorPp2a - Subunit B' - Pr53 IsoformPhosphotyrosyl Phosphatase ActivatorPtpaSerine/Threonine-Protein Phosphatase 2a Regulatory Subunit 4Serine/Threonine-Protein Phosphatase 2a Regulatory Subunit B' |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 2a Activator antibodyAnti-Pp2a - Subunit B' - Pr53 Isoform antibodyAnti-Phosphotyrosyl Phosphatase Activator antibodyAnti-Ptpa antibodyAnti-Serine/Threonine-Protein Phosphatase 2a Regulatory Subunit 4 antibodyAnti-Serine/Threonine-Protein Phosphatase 2a Regulatory Subunit B' antibodyAnti-PTPA antibodyAnti-PPP2R4 antibody |
Information sourced from Uniprot.org