Anti-PPM1D antibody (STJA0009427)

SKU:
STJA0009427
€60.00 - €315.00
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Protein phosphatase 1D is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PPM1D
Gene ID: 8493
Uniprot ID: PPM1D_HUMAN
Specificity: This antibody detects endogenous levels of PPM1D at Human, Mouse
Immunogen: Synthesized peptide derived from human PPM1D
Function Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity.
Protein Name Protein Phosphatase 1d
Protein Phosphatase 2c Isoform Delta
Pp2c-Delta
Protein Phosphatase Magnesium-Dependent 1 Delta
P53-Induced Protein Phosphatase 1
Database Links Reactome: R-HSA-8878166
Cellular Localisation Nucleus
Cytoplasm
Cytosol
Alternative Antibody Names Anti-Protein Phosphatase 1d antibody
Anti-Protein Phosphatase 2c Isoform Delta antibody
Anti-Pp2c-Delta antibody
Anti-Protein Phosphatase Magnesium-Dependent 1 Delta antibody
Anti-P53-Induced Protein Phosphatase 1 antibody
Anti-PPM1D antibody
Anti-WIP1 antibody

Information sourced from Uniprot.org

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