Anti-PPM1D antibody (STJA0009427)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PPM1D
General Information
| Short Description | Rabbit polyclonal anti-Protein phosphatase 1D for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PPM1D |
| Gene ID | 8493 |
| Uniprot ID | PPM1D_HUMAN |
| Immunogen | Synthesized peptide derived from human PPM1D |
| Specificity | This antibody detects endogenous levels of PPM1D at Human, Mouse |
Additional Info
| Function | Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity. |
| Protein Name | Protein Phosphatase 1dProtein Phosphatase 2c Isoform DeltaPp2c-DeltaProtein Phosphatase Magnesium-Dependent 1 DeltaP53-Induced Protein Phosphatase 1 |
| Database Links | Reactome: R-HSA-8878166 |
| Cellular Localisation | NucleusCytoplasmCytosol |
| Alternative Antibody Names | Anti-Protein Phosphatase 1d antibodyAnti-Protein Phosphatase 2c Isoform Delta antibodyAnti-Pp2c-Delta antibodyAnti-Protein Phosphatase Magnesium-Dependent 1 Delta antibodyAnti-P53-Induced Protein Phosphatase 1 antibodyAnti-PPM1D antibodyAnti-WIP1 antibody |
Information sourced from Uniprot.org