Anti-PPM1D antibody (Internal Region) (STJ13101645)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from internal region of mouse PPM1D conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-PPM1D (Internal Region) for use in IHC and WB in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Ppm1d |
| Gene ID | 53892 |
| Uniprot ID | PPM1D_MOUSE |
| Immunogen | A synthetic peptide from internal region of mouse PPM1D conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | Internal Region |
| Specificity | Specific for PPM1D. |
Additional Info
| Function | Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity. |
| Protein Name | Protein Phosphatase 1dProtein Phosphatase 2c Isoform DeltaPp2c-DeltaProtein Phosphatase Magnesium-Dependent 1 DeltaP53-Induced Protein Phosphatase 1 |
| Database Links | Reactome: R-MMU-8878166 |
| Cellular Localisation | NucleusCytoplasmCytosol |
| Alternative Antibody Names | Anti-Protein Phosphatase 1d antibodyAnti-Protein Phosphatase 2c Isoform Delta antibodyAnti-Pp2c-Delta antibodyAnti-Protein Phosphatase Magnesium-Dependent 1 Delta antibodyAnti-P53-Induced Protein Phosphatase 1 antibodyAnti-Ppm1d antibodyAnti-Wip1 antibody |
Information sourced from Uniprot.org