| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PPM1D (Internal Region) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Ppm1d |
| Gene ID: |
53892 |
| Uniprot ID: |
PPM1D_MOUSE |
| Immunogen Region: |
Internal Region |
| Specificity: |
Specific for PPM1D. |
| Immunogen: |
A synthetic peptide from internal region of mouse PPM1D conjugated to an immunogenic carrier protein was used as the antigen. |
| Function | Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity. |
| Protein Name | Protein Phosphatase 1dProtein Phosphatase 2c Isoform DeltaPp2c-DeltaProtein Phosphatase Magnesium-Dependent 1 DeltaP53-Induced Protein Phosphatase 1 |
| Database Links | Reactome: R-MMU-8878166 |
| Cellular Localisation | NucleusCytoplasmCytosol |
| Alternative Antibody Names | Anti-Protein Phosphatase 1d antibodyAnti-Protein Phosphatase 2c Isoform Delta antibodyAnti-Pp2c-Delta antibodyAnti-Protein Phosphatase Magnesium-Dependent 1 Delta antibodyAnti-P53-Induced Protein Phosphatase 1 antibodyAnti-Ppm1d antibodyAnti-Wip1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
