STJ70591 (0. 3µg/ml) staining of MOLT4 lysate (35µg protein in RIPA buffer). Detected by chemiluminescence.

Anti-PPAR delta-Isoform 1 antibody (C-Term) (STJ70591)

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STJ70591-100
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Short Description :Goat polyclonal antibody anti-PPAR delta-Isoform 1 (C-Term) is suitable for use in ELISA and Western Blot research applications.
Applications:Pep-ELISA/WB
Host:Goat
Reactivity:Human/Mouse/Rat/Pig/Cow
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Concentration:0.5 mg/mL
Purification:Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Dilution Range:Peptide ELISA: antibody detection limit dilution 1:32000.
WB: Approx 55kDa band observed in T cell line MOLT4 lysates (calculated MW of 49.9kDa according to NP_006229.1). Recommended concentration: 1-3µg/ml. Primary incubation was 1 hour.
Formulation:0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Storage Instruction:Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol:PPARD
Gene ID:5467
Uniprot ID:PPARD_HUMAN
Accession Number:NP_006229.1
Immunogen Region:C-Term
Immunogen Sequence:CHPLLQEIYKDMY
Specificity:This antibody is expected to recognise isoform 1 (NP_006229) of PPAR delta, but not isoform 2, a shorter protein (NP_803184) with a different C-terminus.
Post Translational Modifications 'Lys-48'-linked polyubiquitinated.leading to proteasomal degradation. Deubiquitinated and stabilized by OTUD3.
Function Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
Protein Name Peroxisome Proliferator-Activated Receptor Delta
Ppar-Delta
Nuci
Nuclear Hormone Receptor 1
Nuc1
Nuclear Receptor Subfamily 1 Group C Member 2
Peroxisome Proliferator-Activated Receptor Beta
Ppar-Beta
Database Links Reactome: R-HSA-200425
Reactome: R-HSA-383280
Reactome: R-HSA-5362517
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Peroxisome Proliferator-Activated Receptor Delta antibody
Anti-Ppar-Delta antibody
Anti-Nuci antibody
Anti-Nuclear Hormone Receptor 1 antibody
Anti-Nuc1 antibody
Anti-Nuclear Receptor Subfamily 1 Group C Member 2 antibody
Anti-Peroxisome Proliferator-Activated Receptor Beta antibody
Anti-Ppar-Beta antibody
Anti-PPARD antibody
Anti-NR1C2 antibody
Anti-PPARB antibody

Information sourced from Uniprot.org

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