| Tissue Specificity | Overexpressed in breast and colon cancer. |
| Post Translational Modifications | Sumoylated, probably by PIAS2. |
| Function | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. |
| Protein Name | Polycomb Protein Suz12Chromatin Precipitated E2f Target 9 ProteinChet 9 ProteinJoined To Jazf1 ProteinSuppressor Of Zeste 12 Protein Homolog |
| Database Links | Reactome: R-HSA-212300Reactome: R-HSA-2559580Reactome: R-HSA-3214841Reactome: R-HSA-4551638Reactome: R-HSA-5617472Reactome: R-HSA-8943724Reactome: R-HSA-8953750Reactome: R-HSA-9609690Reactome: R-HSA-9710421 |
| Cellular Localisation | NucleusLocalizes To Chromatin As Part Of The Prc2 Complex |
| Alternative Antibody Names | Anti-Polycomb Protein Suz12 antibodyAnti-Chromatin Precipitated E2f Target 9 Protein antibodyAnti-Chet 9 Protein antibodyAnti-Joined To Jazf1 Protein antibodyAnti-Suppressor Of Zeste 12 Protein Homolog antibodyAnti-SUZ12 antibodyAnti-CHET9 antibodyAnti-JJAZ1 antibodyAnti-KIAA0160 antibody |
Information sourced from Uniprot.org
![Anti-laminin a4 antibody [6C3] (STJA0002859)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/150125/299831/STJA0002859_1__78075.1633363918.jpg?c=1 "Anti-laminin a4 antibody [6C3] (STJA0002859)")
