| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-POLR3C (1-270) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
POLR3C |
| Gene ID: |
10623 |
| Uniprot ID: |
RPC3_HUMAN |
| Immunogen Region: |
1-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human POLR3C (NP_006459.3). |
| Immunogen Sequence: |
MTQAEIKLCSLLLQEHFGEI VEKIGVHLIRTGSQPLRVIA HDTGTSLDQVKKALCVLVQH NLVSYQVHKRGVVEYEAQCS RVLRMLRYPRYIYTTKTLYS DTGELIVEELLLNGKLTMSA VVKKVADRLTETMEDGKTMD YAEVSNTFVRLADTHFVQRC PSVPTTENSDPGPPPPAPTL VINEKDMYLVPKLSLIGKGK RRRSSDEDAAGEPKAKRPKY TTDNKEPIPDDGIYWQANL |
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner. |
| Protein Name | Dna-Directed Rna Polymerase Iii Subunit Rpc3Rna Polymerase Iii Subunit C3Dna-Directed Rna Polymerase Iii Subunit CRna Polymerase Iii 62 Kda SubunitRpc62 |
| Database Links | Reactome: R-HSA-1834949Reactome: R-HSA-73780Reactome: R-HSA-73980Reactome: R-HSA-749476Reactome: R-HSA-76061Reactome: R-HSA-76066Reactome: R-HSA-76071 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dna-Directed Rna Polymerase Iii Subunit Rpc3 antibodyAnti-Rna Polymerase Iii Subunit C3 antibodyAnti-Dna-Directed Rna Polymerase Iii Subunit C antibodyAnti-Rna Polymerase Iii 62 Kda Subunit antibodyAnti-Rpc62 antibodyAnti-POLR3C antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
