Anti-POLL/POLkappa antibody (C-Term) (STJ70479)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-POLL/POLkappa (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 60kDa band observed in cell lysates of A549 and approx 60-70kDa in cell lysates of HepG2 (calculated MW of 63.5kDa according to Human NP_037406.1). Recommended concentration: 0. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | POLL |
| Gene ID | 27343 |
| Uniprot ID | DPOLL_HUMAN |
| Accession Number | NP_037406.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | LGLPYREPAERDW |
| Specificity | It has been brought to our attention that this product may crossreact with Pol beta (NP_002681) , an evolutionarilly related polymerase with a predicted size of 39 kDa. The overall % of identity is not very high (about 32% in the core) but considerin |
Additional Info
| Function | DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. |
| Protein Name | Dna Polymerase LambdaPol LambdaDna Polymerase Beta-2Pol Beta2Dna Polymerase Kappa |
| Database Links | Reactome: R-HSA-5693571 |
| Cellular Localisation | NucleusChromosomeAccumulates At Sites Of Dna Damage |
| Alternative Antibody Names | Anti-Dna Polymerase Lambda antibodyAnti-Pol Lambda antibodyAnti-Dna Polymerase Beta-2 antibodyAnti-Pol Beta2 antibodyAnti-Dna Polymerase Kappa antibodyAnti-POLL antibody |
Information sourced from Uniprot.org