Anti-POFUT2 antibody (361-410) (STJ94603)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human POFUT2. AA range:361-410
General Information
| Short Description | Rabbit polyclonal anti-GDP-fucose protein O-fucosyltransferase 2 (361-410) for use in IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | POFUT2 |
| Gene ID | 23275 |
| Uniprot ID | OFUT2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human POFUT2. AA range:361-410 |
| Immunogen Region | 361-410 |
| Specificity | O-FucT-2 Polyclonal Antibody detects endogenous levels of O-FucT-2 protein. |
Additional Info
| Tissue Specificity | Isoform A is expressed in fetal liver and peripheral blood lymphocytes. Isoform B is expressed in spleen, lung, testis, bone marrow, thymus, pancreas, prostate, fetal brain, fetal liver and fetal kidney. Isoform C is expressed in brain, heart, spleen, liver, lung, stomach, testis, placenta, skin, thymus, pancreas, mammary gland, prostate, fetal brain, fetal liver and fetal heart. |
| Function | Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families (Probable). Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm. |
| Protein Name | Gdp-Fucose Protein O-Fucosyltransferase 2Peptide-O-Fucosyltransferase 2O-Fuct-2 |
| Database Links | Reactome: R-HSA-5173214 |
| Cellular Localisation | Endoplasmic ReticulumGolgi ApparatusMainly Located In The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Gdp-Fucose Protein O-Fucosyltransferase 2 antibodyAnti-Peptide-O-Fucosyltransferase 2 antibodyAnti-O-Fuct-2 antibodyAnti-POFUT2 antibodyAnti-C21orf80 antibodyAnti-FUT13 antibodyAnti-KIAA0958 antibody |
Information sourced from Uniprot.org