• Immunohistochemistry analysis of paraffin-embedded human placenta tissue, using POFUT2 Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-POFUT2 antibody (361-410) (STJ94603)

SKU:
STJ94603

$62.10 - $305.10
Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-GDP-fucose protein O-fucosyltransferase 2 (361-410) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: POFUT2
Gene ID: 23275
Uniprot ID: OFUT2_HUMAN
Immunogen Region: 361-410
Specificity: O-FucT-2 Polyclonal Antibody detects endogenous levels of O-FucT-2 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from human POFUT2. AA range:361-410
Tissue Specificity Isoform A is expressed in fetal liver and peripheral blood lymphocytes. Isoform B is expressed in spleen, lung, testis, bone marrow, thymus, pancreas, prostate, fetal brain, fetal liver and fetal kidney. Isoform C is expressed in brain, heart, spleen, liver, lung, stomach, testis, placenta, skin, thymus, pancreas, mammary gland, prostate, fetal brain, fetal liver and fetal heart.
Function Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families (Probable). Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm.
Protein Name Gdp-Fucose Protein O-Fucosyltransferase 2
Peptide-O-Fucosyltransferase 2
O-Fuct-2
Database Links Reactome: R-HSA-5173214
Cellular Localisation Endoplasmic Reticulum
Golgi Apparatus
Mainly Located In The Endoplasmic Reticulum
Alternative Antibody Names Anti-Gdp-Fucose Protein O-Fucosyltransferase 2 antibody
Anti-Peptide-O-Fucosyltransferase 2 antibody
Anti-O-Fuct-2 antibody
Anti-POFUT2 antibody
Anti-C21orf80 antibody
Anti-FUT13 antibody
Anti-KIAA0958 antibody

Information sourced from Uniprot.org

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