Anti-PNKD antibody (1-270) (STJ117854)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PNKD (1-270) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PNKD |
| Gene ID | 25953 |
| Uniprot ID | PNKD_HUMAN |
| Immunogen Region | 1-270 |
| Immunogen Sequence | MAAVVAATALKGRGARNARV LRGILAGATANKASHNRTRA LQSHSSPEGKEEPEPLSPEL EYIPRKRGKNPMKAVGLAWY SLYTRTWLGYLFYRQQLRRA RNRYPKGHSKTQPRLFNGVK VLPIPVLSDNYSYLIIDTQA QLAVAVDPSDPRAVQASIEK EGVTLVAILCTHKHWDHSGG NRDLSRRHRDCRVYGSPQDG IPYLTHPLCHQDVVSVGRLQ IRALATPGHTQGHLVYLLD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human PNKD (NP_056303.3). |
Additional Info
| Tissue Specificity | Isoform 1 is only expressed in the brain. Isoform 2 is ubiquitously detected with highest expression in skeletal muscle and detected in myocardial myofibrils. |
| Post Translational Modifications | Undergoes cleavage at the N-terminus. |
| Function | Probable thioesterase that may play a role in cellular detoxification processes.it likely acts on a yet-unknown alpha-hydroxythioester substrate (Probable). In vitro, it is able to catalyze the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid at very low rate, though this reaction is not physiologically relevant in vivo. |
| Protein Name | Probable Thioesterase PnkdMyofibrillogenesis Regulator 1Mr-1Paroxysmal Nonkinesiogenic Dyskinesia ProteinTrans-Activated By Hepatitis C Virus Core Protein 2 |
| Database Links | Reactome: R-HSA-9864848 Q8N490-2 |
| Cellular Localisation | Isoform 1: Cell MembranePeripheral Membrane ProteinMitochondrionIsoform 2: CytoplasmIsoform 3: MitochondrionGolgi ApparatusEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Probable Thioesterase Pnkd antibodyAnti-Myofibrillogenesis Regulator 1 antibodyAnti-Mr-1 antibodyAnti-Paroxysmal Nonkinesiogenic Dyskinesia Protein antibodyAnti-Trans-Activated By Hepatitis C Virus Core Protein 2 antibodyAnti-PNKD antibodyAnti-KIAA1184 antibodyAnti-MR1 antibodyAnti-TAHCCP2 antibodyAnti-FKSG19 antibodyAnti-UNQ2491 antibodyAnti-PRO5778 antibody |
Information sourced from Uniprot.org