Host: | Rabbit |
Applications: | WB/IF |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit monoclonal antibody anti-PMP70/ABCD3 (560-659) is suitable for use in Western Blot and Immunofluorescence research applications. |
Clonality: | Monoclonal |
Clone ID: | S8MR |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:1000 IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | ABCD3 |
Gene ID: | 5825 |
Uniprot ID: | ABCD3_HUMAN |
Immunogen Region: | 560-659 |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 560-659 of human PMP70/ABCD3 (P28288). |
Immunogen Sequence: | GWDSVQDWMDVLSGGEKQRM AMARLFYHKPQFAILDECTS AVSVDVEGYIYSHCRKVGIT LFTVSHRKSLWKHHEYYLHM DGRGNYEFKQITEDTVEFGS |
Post Translational Modifications | Ubiquitinated by PEX2 during pexophagy in response to starvation, leading to its degradation. |
Function | Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation. Has fatty acyl-CoA thioesterase and ATPase activities. Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes. Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation. |
Protein Name | Atp-Binding Cassette Sub-Family D Member 3 70 Kda Peroxisomal Membrane Protein Pmp70 |
Database Links | Reactome: R-HSA-1369062 Reactome: R-HSA-8980692 Reactome: R-HSA-9013106 Reactome: R-HSA-9603798 |
Cellular Localisation | Peroxisome Membrane Multi-Pass Membrane Protein |
Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family D Member 3 antibody Anti-70 Kda Peroxisomal Membrane Protein antibody Anti-Pmp70 antibody Anti-ABCD3 antibody Anti-PMP70 antibody Anti-PXMP1 antibody |
Information sourced from Uniprot.org