Anti-PMP70/ABCD3 antibody (560-659) [S8MR] (STJ11103558)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal PMP70/ABCD3 (560-659) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S8MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:6000IF/ICC:1:200-1:800ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ABCD3 |
| Gene ID | 5825 |
| Uniprot ID | ABCD3_HUMAN |
| Immunogen Region | 560-659 |
| Immunogen Sequence | GWDSVQDWMDVLSGGEKQRM AMARLFYHKPQFAILDECTS AVSVDVEGYIYSHCRKVGIT LFTVSHRKSLWKHHEYYLHM DGRGNYEFKQITEDTVEFGS |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 560-659 of human PMP70/ABCD3 (P28288). |
Additional Info
| Post Translational Modifications | Ubiquitinated by PEX2 during pexophagy in response to starvation, leading to its degradation. |
| Function | Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation. Has fatty acyl-CoA thioesterase and ATPase activities. Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes. Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation. |
| Protein Name | Atp-Binding Cassette Sub-Family D Member 370 Kda Peroxisomal Membrane ProteinPmp70 |
| Database Links | Reactome: R-HSA-1369062Reactome: R-HSA-8980692Reactome: R-HSA-9013106Reactome: R-HSA-9603798 |
| Cellular Localisation | Peroxisome MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family D Member 3 antibodyAnti-70 Kda Peroxisomal Membrane Protein antibodyAnti-Pmp70 antibodyAnti-ABCD3 antibodyAnti-PMP70 antibodyAnti-PXMP1 antibody |
Information sourced from Uniprot.org