| Host: |
Rabbit |
| Applications: |
IHC/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Pro-MCH (112-161 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC-P 1:50-200ELISA 1:10000-20000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PMCH |
| Gene ID: |
5367 |
| Uniprot ID: |
MCH_HUMAN |
| Immunogen Region: |
112-161 aa |
| Specificity: |
The antibody detects endogenous PMCH |
| Immunogen: |
Synthetic peptide from the human protein at the amino acid range 112-161 |
| Post Translational Modifications | Differentially processed in the brain and in peripheral organs producing two neuropeptides.NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. |
| Function | MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation. |
| Protein Name | Pro-Mch Cleaved Into - Neuropeptide-Glycine-Glutamic AcidNgeNeuropeptide G-E - Neuropeptide-Glutamic Acid-IsoleucineNeiNeuropeptide E-I - Melanin-Concentrating HormoneMch |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476Reactome: R-HSA-418594 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Pro-Mch Cleaved Into - Neuropeptide-Glycine-Glutamic Acid antibodyAnti-Nge antibodyAnti-Neuropeptide G-E - Neuropeptide-Glutamic Acid-Isoleucine antibodyAnti-Nei antibodyAnti-Neuropeptide E-I - Melanin-Concentrating Hormone antibodyAnti-Mch antibodyAnti-PMCH antibodyAnti-MCH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
