| Post Translational Modifications | Differentially processed in the brain and in peripheral organs producing two neuropeptides.NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. |
| Function | MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation. |
| Protein Name | Pro-Mch Cleaved Into - Neuropeptide-Glycine-Glutamic AcidNgeNeuropeptide G-E - Neuropeptide-Glutamic Acid-IsoleucineNeiNeuropeptide E-I - Melanin-Concentrating HormoneMch |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476Reactome: R-HSA-418594 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Pro-Mch Cleaved Into - Neuropeptide-Glycine-Glutamic Acid antibodyAnti-Nge antibodyAnti-Neuropeptide G-E - Neuropeptide-Glutamic Acid-Isoleucine antibodyAnti-Nei antibodyAnti-Neuropeptide E-I - Melanin-Concentrating Hormone antibodyAnti-Mch antibodyAnti-PMCH antibodyAnti-MCH antibody |
Information sourced from Uniprot.org
