Anti-PLCD3 antibody (261-274) (STJ73778)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-PLCD3 (261-274) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 85kDa band observed in lysates of cell limes A549 and Caco-2, and in preliminary testing of cell lines HeLa, HEK293 and U251 lysate (calculated MW of 89.3kDa according to NP_588 |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PLCD3 |
| Gene ID | 113026 |
| Uniprot ID | PLCD3_HUMAN |
| Accession Number | NP_588614.1 |
| Immunogen Region | 261-274 |
| Immunogen Sequence | HQYSGEDRVLSAPE |
Additional Info
| Function | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Delta-3Phosphoinositide Phospholipase C-Delta-3Phospholipase C-Delta-3Plc-Delta-3 |
| Database Links | Reactome: R-HSA-1855204 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmCleavage FurrowLocalizes At The Cleavage Furrow During Cytokinesis |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Delta-3 antibodyAnti-Phosphoinositide Phospholipase C-Delta-3 antibodyAnti-Phospholipase C-Delta-3 antibodyAnti-Plc-Delta-3 antibodyAnti-PLCD3 antibodyAnti-KIAA1964 antibody |
Information sourced from Uniprot.org