| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human/Mouse/Rat/Dog/Pig/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-PLCD3 (261-274) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:32000.WB: Recommended concentration: 1-3µg/ml.Paraffin embedded Human Kidney and Testis. Recommended concentration: 6µg/ml. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
PLCD3 |
| Gene ID: |
113026 |
| Uniprot ID: |
PLCD3_HUMAN |
| Immunogen Region: |
261-274 |
| Accession Number: |
NP_588614.1 |
| Immunogen Sequence: |
HQYSGEDRVLSAPE |
| Function | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Delta-3Phosphoinositide Phospholipase C-Delta-3Phospholipase C-Delta-3Plc-Delta-3 |
| Database Links | Reactome: R-HSA-1855204 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmCleavage FurrowLocalizes At The Cleavage Furrow During Cytokinesis |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Delta-3 antibodyAnti-Phosphoinositide Phospholipase C-Delta-3 antibodyAnti-Phospholipase C-Delta-3 antibodyAnti-Plc-Delta-3 antibodyAnti-PLCD3 antibodyAnti-KIAA1964 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
