| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PLA2G1B (23-148) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:100-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLA2G1B |
| Gene ID: |
5319 |
| Uniprot ID: |
PA21B_HUMAN |
| Immunogen Region: |
23-148 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 23-148 of human PLA2G1B (NP_000919.1). |
| Immunogen Sequence: |
AVWQFRKMIKCVIPGSDPFL EYNNYGCYCGLGGSGTPVDE LDKCCQTHDNCYDQAKKLDS CKFLLDNPYTHTYSYSCSGS AITCSSKNKECEAFICNCDR NAAICFSKAPYNKAHKNLDT KKYCQS |
| Tissue Specificity | Selectively expressed in pancreas, lung, liver and kidney. Also detected at lower levels in ovary and testis. |
| Post Translational Modifications | Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically. |
| Function | Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. May act in an autocrine and paracrine manner. Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis. Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity. |
| Protein Name | Phospholipase A2Group Ib Phospholipase A2Phosphatidylcholine 2-Acylhydrolase 1b |
| Database Links | Reactome: R-HSA-1482788Reactome: R-HSA-1482801Reactome: R-HSA-1482839Reactome: R-HSA-1482922Reactome: R-HSA-1482925Reactome: R-HSA-1483166 |
| Cellular Localisation | SecretedSecreted From Pancreatic Acinar Cells In Its Inactive Form |
| Alternative Antibody Names | Anti-Phospholipase A2 antibodyAnti-Group Ib Phospholipase A2 antibodyAnti-Phosphatidylcholine 2-Acylhydrolase 1b antibodyAnti-PLA2G1B antibodyAnti-PLA2 antibodyAnti-PLA2A antibodyAnti-PPLA2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
