| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PITX2 |
| Gene ID: | 5308 |
| Uniprot ID: | PITX2_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Pituitary homeobox 2 (PITX2) (NP_000316.2). |
| Immunogen Sequence: | MNCMKGPLHLEHRAAGTKLS AVSSSSCHHPQPLAMASVLA PGQPRSLDSSKHRLEVHTIS DTSSPEAAEKDKSQQGKNED VGAEDPSKKKRQRRQRTHFT |
| Post Translational Modifications | Phosphorylated at Thr-90 by AKT2, but not AKT1. Phosphorylation impairs its association with a CCND1 mRNA-stabilizing complex, thus shortening the half-life of CCND1. |
| Function | May play a role in myoblast differentiation. When unphosphorylated, associates with an ELAVL1-containing complex, which stabilizes cyclin mRNA and ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation. Isoform PTX2C: Involved in the establishment of left-right asymmetry in the developing embryo. |
| Protein Name | Pituitary Homeobox 2 All1-Responsive Protein Arp1 Homeobox Protein Pitx2 Paired-Like Homeodomain Transcription Factor 2 Rieg Bicoid-Related Homeobox Transcription Factor Solurshin |
| Database Links | Reactome: R-HSA-8866906 |
| Cellular Localisation | Nucleus Cytoplasm |
| Alternative Antibody Names | Anti-Pituitary Homeobox 2 antibody Anti-All1-Responsive Protein Arp1 antibody Anti-Homeobox Protein Pitx2 antibody Anti-Paired-Like Homeodomain Transcription Factor 2 antibody Anti-Rieg Bicoid-Related Homeobox Transcription Factor antibody Anti-Solurshin antibody Anti-PITX2 antibody Anti-ARP1 antibody Anti-RGS antibody Anti-RIEG antibody Anti-RIEG1 antibody |
Information sourced from Uniprot.org