Anti-PITX2 antibody (1-100) [S4743RM] (STJ11104743)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Pituitary Homeobox 2 (1-100) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4743RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PITX2 |
| Gene ID | 5308 |
| Uniprot ID | PITX2_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | METNCRKLVSACVQLGVQPA AVECLFSKDSEIKKVEFTDS PESRKEAASSKFFPRQHPGA NEKDKSQQGKNEDVGAEDPS KKKRQRRQRTHFTSQQLQEL |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Pituitary homeobox 2 (PITX2) (NP_700475.1). |
Additional Info
| Post Translational Modifications | Phosphorylated at Thr-90 by AKT2, but not AKT1. Phosphorylation impairs its association with a CCND1 mRNA-stabilizing complex, thus shortening the half-life of CCND1. |
| Function | May play a role in myoblast differentiation. When unphosphorylated, associates with an ELAVL1-containing complex, which stabilizes cyclin mRNA and ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation. Isoform PTX2C: Involved in the establishment of left-right asymmetry in the developing embryo. |
| Protein Name | Pituitary Homeobox 2All1-Responsive Protein Arp1Homeobox Protein Pitx2Paired-Like Homeodomain Transcription Factor 2Rieg Bicoid-Related Homeobox Transcription FactorSolurshin |
| Database Links | Reactome: R-HSA-8866906 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Pituitary Homeobox 2 antibodyAnti-All1-Responsive Protein Arp1 antibodyAnti-Homeobox Protein Pitx2 antibodyAnti-Paired-Like Homeodomain Transcription Factor 2 antibodyAnti-Rieg Bicoid-Related Homeobox Transcription Factor antibodyAnti-Solurshin antibodyAnti-PITX2 antibodyAnti-ARP1 antibodyAnti-RGS antibodyAnti-RIEG antibodyAnti-RIEG1 antibody |
Information sourced from Uniprot.org