Anti-PITX2 antibody (142-192) (STJA0006624)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PITX2 AA range: 142-192
General Information
| Short Description | Rabbit polyclonal anti-Pituitary homeobox 2 (142-192) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PITX2 |
| Gene ID | 5308 |
| Uniprot ID | PITX2_HUMAN |
| Immunogen | Synthesized peptide derived from human PITX2 AA range: 142-192 |
| Immunogen Region | 142-192 |
| Specificity | This antibody detects endogenous levels of human PITX2 |
Additional Info
| Function | May play a role in myoblast differentiation. When unphosphorylated, associates with an ELAVL1-containing complex, which stabilizes cyclin mRNA and ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation. Isoform PTX2C: Involved in the establishment of left-right asymmetry in the developing embryo. |
| Protein Name | Pituitary Homeobox 2All1-Responsive Protein Arp1Homeobox Protein Pitx2Paired-Like Homeodomain Transcription Factor 2Rieg Bicoid-Related Homeobox Transcription FactorSolurshin |
| Database Links | Reactome: R-HSA-8866906 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Pituitary Homeobox 2 antibodyAnti-All1-Responsive Protein Arp1 antibodyAnti-Homeobox Protein Pitx2 antibodyAnti-Paired-Like Homeodomain Transcription Factor 2 antibodyAnti-Rieg Bicoid-Related Homeobox Transcription Factor antibodyAnti-Solurshin antibodyAnti-PITX2 antibodyAnti-ARP1 antibodyAnti-RGS antibodyAnti-RIEG antibodyAnti-RIEG1 antibody |
Information sourced from Uniprot.org