| Post Translational Modifications | Phosphorylated at Thr-90 by AKT2, but not AKT1. Phosphorylation impairs its association with a CCND1 mRNA-stabilizing complex, thus shortening the half-life of CCND1. |
| Function | May play a role in myoblast differentiation. When unphosphorylated, associates with an ELAVL1-containing complex, which stabilizes cyclin mRNA and ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation. Isoform PTX2C: Involved in the establishment of left-right asymmetry in the developing embryo. |
| Protein Name | Pituitary Homeobox 2All1-Responsive Protein Arp1Homeobox Protein Pitx2Paired-Like Homeodomain Transcription Factor 2Rieg Bicoid-Related Homeobox Transcription FactorSolurshin |
| Database Links | Reactome: R-HSA-8866906 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Pituitary Homeobox 2 antibodyAnti-All1-Responsive Protein Arp1 antibodyAnti-Homeobox Protein Pitx2 antibodyAnti-Paired-Like Homeodomain Transcription Factor 2 antibodyAnti-Rieg Bicoid-Related Homeobox Transcription Factor antibodyAnti-Solurshin antibodyAnti-PITX2 antibodyAnti-ARP1 antibodyAnti-RGS antibodyAnti-RIEG antibodyAnti-RIEG1 antibody |
Information sourced from Uniprot.org
