Anti-PINX1 antibody (N-Term) (STJ70126)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-PINX1 (N-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Pig/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:4000.WB: Approx 35kDa band seen in Jurkat lysate. Recommended for use at 1-3µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PINX1 |
| Gene ID | 54984 |
| Uniprot ID | PINX1_HUMAN |
| Accession Number | NP_060354.4 |
| Immunogen Region | N-Term |
| Immunogen Sequence | SMLAERRRKQKWAV |
Additional Info
| Post Translational Modifications | Cleaved by enterovirus protease 3C to promote apoptosis. |
| Function | Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. |
| Protein Name | Pin2/Terf1-Interacting Telomerase Inhibitor 1Liver-Related Putative Tumor SuppressorPin2-Interacting Protein X1Protein 67-11-3Trf1-Interacting Protein 1 |
| Cellular Localisation | NucleusNucleolusChromosomeTelomereCentromereKinetochoreLocalizes In NucleoliAt Telomere Speckles And To The Outer Plate Of KinetochoresLocalization To The Kinetochore Is Mediated By Its Central Region And Depends On Ndc80 And Cenpe |
| Alternative Antibody Names | Anti-Pin2/Terf1-Interacting Telomerase Inhibitor 1 antibodyAnti-Liver-Related Putative Tumor Suppressor antibodyAnti-Pin2-Interacting Protein X1 antibodyAnti-Protein 67-11-3 antibodyAnti-Trf1-Interacting Protein 1 antibodyAnti-PINX1 antibodyAnti-LPTL antibodyAnti-LPTS antibody |
Information sourced from Uniprot.org