Anti-PIK3CB antibody (STJ191945)

SKU:
STJ191945

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phosphatidylinositol 4, 5-bisphosphate 3-kinase catalytic subunit beta isoform is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PIK3CB
Gene ID: 5291
Uniprot ID: PK3CB_HUMAN
Specificity: PK3CB Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Post Translational Modifications Autophosphorylation at Ser-1070 negatively regulates the phosphatidylinositol-4,5-bisphosphate 3-kinase activity.
Function Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. Has also a protein kinase activity showing autophosphorylation.
Protein Name Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform
Pi3-Kinase Subunit Beta
Pi3k-Beta
Pi3kbeta
Ptdins-3-Kinase Subunit Beta
Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase 110 Kda Catalytic Subunit Beta
Ptdins-3-Kinase Subunit P110-Beta
P110beta
Serine/Threonine Protein Kinase Pik3cb
Database Links Reactome: R-HSA-109704
Reactome: R-HSA-112399
Reactome: R-HSA-114604
Reactome: R-HSA-1257604
Reactome: R-HSA-1660499
Reactome: R-HSA-186763
Reactome: R-HSA-198203
Reactome: R-HSA-201556
Reactome: R-HSA-202424
Reactome: R-HSA-2029485
Reactome: R-HSA-210993
Reactome: R-HSA-2219530
Reactome: R-HSA-2424491
Reactome: R-HSA-2730905
Reactome: R-HSA-373753
Reactome: R-HSA-4420097
Reactome: R-HSA-512988
Reactome: R-HSA-5673001
Reactome: R-HSA-6811558
Reactome: R-HSA-8853659
Reactome: R-HSA-9027276
Reactome: R-HSA-912526
Reactome: R-HSA-912631
Reactome: R-HSA-9673767
Reactome: R-HSA-9673770
Reactome: R-HSA-9680350
Cellular Localisation Cytoplasm
Nucleus
Interaction With Pik3r2 Is Required For Nuclear Localization And Export
Alternative Antibody Names Anti-Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform antibody
Anti-Pi3-Kinase Subunit Beta antibody
Anti-Pi3k-Beta antibody
Anti-Pi3kbeta antibody
Anti-Ptdins-3-Kinase Subunit Beta antibody
Anti-Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase 110 Kda Catalytic Subunit Beta antibody
Anti-Ptdins-3-Kinase Subunit P110-Beta antibody
Anti-P110beta antibody
Anti-Serine/Threonine Protein Kinase Pik3cb antibody
Anti-PIK3CB antibody
Anti-PIK3C1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance