| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phosphatidylinositol 4, 5-bisphosphate 3-kinase catalytic subunit beta isoform is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PIK3CB |
| Gene ID: | 5291 |
| Uniprot ID: | PK3CB_HUMAN |
| Specificity: | PK3CB Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | Autophosphorylation at Ser-1070 negatively regulates the phosphatidylinositol-4,5-bisphosphate 3-kinase activity. |
| Function | Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. Has also a protein kinase activity showing autophosphorylation. |
| Protein Name | Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform Pi3-Kinase Subunit Beta Pi3k-Beta Pi3kbeta Ptdins-3-Kinase Subunit Beta Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase 110 Kda Catalytic Subunit Beta Ptdins-3-Kinase Subunit P110-Beta P110beta Serine/Threonine Protein Kinase Pik3cb |
| Database Links | Reactome: R-HSA-109704 Reactome: R-HSA-112399 Reactome: R-HSA-114604 Reactome: R-HSA-1257604 Reactome: R-HSA-1660499 Reactome: R-HSA-186763 Reactome: R-HSA-198203 Reactome: R-HSA-201556 Reactome: R-HSA-202424 Reactome: R-HSA-2029485 Reactome: R-HSA-210993 Reactome: R-HSA-2219530 Reactome: R-HSA-2424491 Reactome: R-HSA-2730905 Reactome: R-HSA-373753 Reactome: R-HSA-4420097 Reactome: R-HSA-512988 Reactome: R-HSA-5673001 Reactome: R-HSA-6811558 Reactome: R-HSA-8853659 Reactome: R-HSA-9027276 Reactome: R-HSA-912526 Reactome: R-HSA-912631 Reactome: R-HSA-9673767 Reactome: R-HSA-9673770 Reactome: R-HSA-9680350 Reactome: R-HSA-9725370 Reactome: R-HSA-9842640 Reactome: R-HSA-9842663 |
| Cellular Localisation | Cytoplasm Nucleus Interaction With Pik3r2 Is Required For Nuclear Localization And Export |
| Alternative Antibody Names | Anti-Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform antibody Anti-Pi3-Kinase Subunit Beta antibody Anti-Pi3k-Beta antibody Anti-Pi3kbeta antibody Anti-Ptdins-3-Kinase Subunit Beta antibody Anti-Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase 110 Kda Catalytic Subunit Beta antibody Anti-Ptdins-3-Kinase Subunit P110-Beta antibody Anti-P110beta antibody Anti-Serine/Threonine Protein Kinase Pik3cb antibody Anti-PIK3CB antibody Anti-PIK3C1 antibody |
Information sourced from Uniprot.org