| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PIH1D1 (1-290) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PIH1D1 |
| Gene ID: |
55011 |
| Uniprot ID: |
PIHD1_HUMAN |
| Immunogen Region: |
1-290 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human PIH1D1 (NP_060386.1). |
| Immunogen Sequence: |
MANPKLLGMGLSEAEAIGAD SARFEELLLQASKELQQAQT TRPESTQIQPQPGFCIKTNS SEGKVFINICHSPSIPPPAD VTEEELLQMLEEDQAGFRIP MSLGEPHAELDAKGQGCTAY DVAVNSDFYRRMQNSDFLRE LVITIAREGLEDKYNLQLNP EWRMMKNRPFMGSISQQNIR SEQRPRIQELGDLYTPAPGR AESGPEKPHLNLWLEAPDLL LAEVDLPKLDGALGLSLEI |
| Tissue Specificity | Expressed at low levels in normal mammary epithelial cells (at protein level). Highest expression in lung, leukocyte and placenta. Expressed at lower levels in brain, prostate, colon, heart, small intestine, liver, ovary, pancreas, skeletal muscle, spleen, testis and thymus. |
| Function | Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex. |
| Protein Name | Pih1 Domain-Containing Protein 1Nucleolar Protein 17 Homolog |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pih1 Domain-Containing Protein 1 antibodyAnti-Nucleolar Protein 17 Homolog antibodyAnti-PIH1D1 antibodyAnti-NOP17 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and MSH6 knockout (KO) HeLa cells, using [KO Validated] MSH6 Rabbit polyclonal antibody (STJ119980) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/98765/382817/STJ119980_1__09948.1713151312.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and MSH6 knockout (KO) HeLa cells, using [KO Validated] MSH6 Rabbit polyclonal antibody (STJ119980) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.")
