| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PI4K2B (1-120) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PI4K2B |
| Gene ID: |
55300 |
| Uniprot ID: |
P4K2B_HUMAN |
| Immunogen Region: |
1-120 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human PI4K2B (NP_060793.2). |
| Immunogen Sequence: |
MEDPSEPDRLASADGGSPEE EEDGEREPLLPRIAWAHPRR GAPGSAVRLLDAAGEEGEAG DEELPLPPGDVGVSRSSSAE LDRSRPAVSVTIGTSEMNAF LDDPEFADIMLRAEQAIEVG |
| Tissue Specificity | Widely expressed. |
| Function | Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. |
| Protein Name | Phosphatidylinositol 4-Kinase Type 2-BetaPhosphatidylinositol 4-Kinase Type Ii-BetaPi4kii-Beta |
| Database Links | Reactome: R-HSA-1483248Reactome: R-HSA-1660499Reactome: R-HSA-1660514Reactome: R-HSA-1660516 |
| Cellular Localisation | CytoplasmCytosolGolgi Apparatus MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneCell MembraneEarly Endosome MembraneMainly CytosolicAssociation With Membranes Of The GolgiEndoplasmic And Plasma Membrane Is Stimulated By Active Rac1Association With Early Endosomes Has Not Been Confirmed |
| Alternative Antibody Names | Anti-Phosphatidylinositol 4-Kinase Type 2-Beta antibodyAnti-Phosphatidylinositol 4-Kinase Type Ii-Beta antibodyAnti-Pi4kii-Beta antibodyAnti-PI4K2B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
