| Tissue Specificity | Widely expressed. |
| Function | Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. |
| Protein Name | Phosphatidylinositol 4-Kinase Type 2-BetaPhosphatidylinositol 4-Kinase Type Ii-BetaPi4kii-Beta |
| Database Links | Reactome: R-HSA-1483248Reactome: R-HSA-1660499Reactome: R-HSA-1660514Reactome: R-HSA-1660516 |
| Cellular Localisation | CytoplasmCytosolGolgi Apparatus MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneCell MembraneEarly Endosome MembraneMainly CytosolicAssociation With Membranes Of The GolgiEndoplasmic And Plasma Membrane Is Stimulated By Active Rac1Association With Early Endosomes Has Not Been Confirmed |
| Alternative Antibody Names | Anti-Phosphatidylinositol 4-Kinase Type 2-Beta antibodyAnti-Phosphatidylinositol 4-Kinase Type Ii-Beta antibodyAnti-Pi4kii-Beta antibodyAnti-PI4K2B antibody |
Information sourced from Uniprot.org
