• Western blot analysis of lysates from HeLa cells treated with IFN 2500U/ml 30', using STAT2 (Phospho-Tyr690) Antibody. The lane on the right is blocked with the phospho peptide.
  • Western blot analysis of various cells using Phospho-Stat2 (Y690) Polyclonal Antibody
  • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using STAT2 (Phospho-Tyr690) Antibody. The picture on the right is blocked with the phospho peptide.
  • Western blot analysis of Stat2 (phospho Tyr690) Polyclonal Antibody, using Hela, Jurkat cell treated or untreated with IFN 2500U/ml 30', 4°C over night, secondary antibody (cat： (NA was diluted at 1:10000, 37°C 1hour.

Anti-Phospho-STAT2-Tyr690 antibody (656-705 aa) (STJ90772)

SKU:
STJ90772

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Signal transducer and activator of transcription 2-Tyr690 (656-705 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: STAT2
Gene ID: 6773
Uniprot ID: STAT2_HUMAN
Immunogen Region: 656-705 aa
Specificity: Phospho-Stat2 (Y690) Polyclonal Antibody detects endogenous levels of Stat2 protein only when phosphorylated at Y690.
Immunogen: The antiserum was produced against synthesized peptide derived from the human STAT2 around the phosphorylation site of Tyr690 at the amino acid range 656-705
Function Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In addition, has also a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs. Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively.
Protein Name Signal Transducer And Activator Of Transcription 2
P113
Database Links Reactome: R-HSA-8854691
Reactome: R-HSA-909733
Reactome: R-HSA-912694
Reactome: R-HSA-9679191
Reactome: R-HSA-9705671
Cellular Localisation Cytoplasm
Nucleus
Translocated Into The Nucleus Upon Activation By Ifn-Alpha/Beta
Alternative Antibody Names Anti-Signal Transducer And Activator Of Transcription 2 antibody
Anti-P113 antibody
Anti-STAT2 antibody

Information sourced from Uniprot.org

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